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Kettle, J.G., Anjum, R., Barry, E., Bhavsar, D., Brown, C., Boyd, S., Campbell, A., Goldberg, K., Grondine, M., Guichard, S., Hardy, C.J., Hunt, T., Jones, R.D.O., Xiuwei Li, X., Moleva, O., Ogg, D., Overman, R.C., Packer, M.J., Pearson, S., Schimpl, M., Shao, W., Smith, A., Smith, J.M., Stead, D., Stokes, S., Tucker, M., Ye, Y. "Discovery of N‑(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)‑1H‑1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors". Journal of Medicinal Chemistry., on line first (25/09/2018): (2018).
Herrera-Morande, A., Castro-Fernández, V., Merino, F., Ramírez-Sarmiento, C., Fernández, F.J., Vega, M.C., Guixé, V. "Protein topology determines substrate-binding mechanism in homologous enzymes" Biochemica et Biophysica Acta (BBA) - General Subjects., 1862(12): 2869-2878. (2018).
Tran, N.V., Muller, L., Ross, R.L., Lestini, R., Létoquart, J., Ulryck, N., Limbach, P.A., de Crécy-Lagard, V., Cianférani, S., Graille, M. "Evolutionary insights into Trm112-methyltransferase holoenzymes involved in translation between archaea and eukaryotes" Nucleic Acids Research., 46(16): 8483-8499. (2018).
Henri, J., Chagot, M.E., Bourguet, M., Abel, Y., Terral, G., Maurizy, C., Aigueperse, C., Georgescauld, F., Vandermoere, F., Saint-Fort, R., Behm-Ansmant, I., Charpentier, B., Pradet-Balade, B., Verheggen, C., Bertrand, E., Meyer, P., Cianférani, S., Manival, X., Quinternet, M. "Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex" Structure., 26(9): 1196-1209.e8. (2018).
Huyet, J., Ozeir, M., Burgevin, M.C., Pinson, B., Chesney, F., Remy, J.M., Siddiqi, A.R., Lupoli, R., Pinon, G., Saint-Marc, C., Gibert, J.F., Morales, R., Ceballos-Picot, I., Barouki, R., Daignan-Fornier, B., Olivier-Bandini, A., Augé, F., Nioche, P. "Structural Insights into the Forward and Reverse Enzymatic Reactions in Human Adenine Phosphoribosyltransferase" Cell Chemical Biology., 25(6): 666-676.e4. (2018).
Issa, K.H.B., Phan, G., Broutin, I. "Functional Mechanism of the Efflux Pumps Transcription Regulators From Pseudomonas aeruginosa Based on 3D Structures" Frontiers in Molecular Biosciences., 5: art.n° 57. (2018).
Joret, C., Capeyrou, R., Belhabich-Baumas, K., Plisson-Chastang, C., Ghandour, R., Humbert, O., Fribourg, S., Leulliot, N., Lebaron, S., Henras, A.K., Henry, Y. "The Npa1p complex chaperones the assembly of the earliest eukaryotic large ribosomal subunit precursor" PLoS Genetics., 14(8): art.n° e1007597. (2018).
Bou-Nader, C., Brégeon, D., Pecqueur, L., Fontecave, M., Hamdane, D. "Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases" Biochemistry., 57(37): 5407–5414. (2018).
Ciccone, L., Fruchart-Gaillard, C., Mourier, G., Savko, M., Nencetti, S., Orlandini, E., Servent, D., Stura, E.A., Shepard, W. "Copper mediated amyloid-β binding to Transthyretin" Scientific Reports., 8: art.n° 13744. (2018).
Royappa, A.T., Tran, C.M., Papoular, R.J., Khan, M., Marbella, L.E., Millstone, J.E., Gembicky, M., Chen, B., Shepard, W., Elkaim, E. "Copper(I) and Gold(I) Thiolate Precursors to Bimetallic Nanoparticles" Polyhedron., 155: 359-365. (2018).