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Dernière mise à jour : 10.05.2023
Fournier, J.F., Clary, L., Chambon, S., Dumais, L., Harris, C.S., Millois-Barbuis, C., Pierre, R., Talano, S., Thoreau, E., Aubert, J., Aurelly, M., Bouix-Peter, C., Brethon, A., Chantalat, L., Christin, O., Comino, C., El-Bazbouz, G., Ghilini, A.L., Isabet, T., Lardy, C., Luzy, A.P., Mathieu, C., Mebrouk, K., Orfila, D., Pascau, J., Reverse, K., Roche, D., Rodeschini, V., Hennequin, L.F. "Rational Drug Design of Topically Administered Caspase 1 Inhibitors for the Treatment of Inflammatory Acne" Journal of Medicinal Chemistry., 61(9): 4030-4051. (2018).
Powell, J., Mota, F., Steadman, D., Soudy, C., Miyauchi, J.T., Crosby, S., Jarvis, A., Reisinge, T., Winfield, N., Evans, G., Finniear, A., Yelland, T., Chou, Y.T., Chan, A.W.E., O'Leary, A., Cheng, L., Liu, D., Fotinou, N., Milagre, C., Martin, J.F., Jia, H., Frankel, P., Djordjevic, S., Tsirka, S.E., Zachary, I.C., Selwood, D.L. "Small molecule neuropilin-1 antagonists combine anti-angiogenic and anti-tumour activity with immune modulation through reduction of transforming growth factor beta (TGF#) production in regulatory T-cells" Journal of Medicinal Chemistry., 61(9): 4135-4154. (2018).
Bule, P., Pires, V.M.R., Alves, V.D., Carvalho, A.L., Prates, J.A.M., Ferreira, L.M.A., Smith, S.P., Gilbert, H.J., Noach, I., Bayer, E.A., Najmudin, S., Fontes, C.M.G.A. "Higher order scaffoldin assembly in Ruminococcus flavefaciens cellulosome is coordinated by a discrete cohesin-dockerin interaction" Scientific Reports., 8: art.n° 6987. (2018).
Capper, M.J., Wright, G.S.A., Barbieri, L., Luchinat, E., Mercatelli, E., McAlary, L., Yerbury, J.J., O’Neill, P.M., Antonyuk, S.V., Banci, L., Hasnain, S. "The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation" Nature Communications., 9: art.n° 1693. (2018).
Fourati, Z., Howard, R.J., Heusser, S.A., Hu, H., Ruza, R.R., Sauguet, L., Lindahl, E., Delarue, M. "Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels" Cell Reports., 23(4): 993–1004. (2018).
Hu, H., Nemecz, A., Van Renterghem, C., Fourati, Z., Sauguet, L., Corringer, P.J., Delarue, M. "Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation" PNAS., 115(17): E3959-E3968. (2018).
Badilla, C., Osborne, T.H., Cole, A., Watson, C., Djordjevic, S., Santini, J.M. "A new family of periplasmic-binding proteins that sense arsenic oxyanions" Scientific Reports., 8: art.n° 6282. (2018).
Williams, A.H., Wheeler, R., Rateau, L., Malosse, C., Chamot-Rooke, J., Haouz, A., Taha, M.K., Boneca, I.G. "A step-by-step in crystallo guide to bond cleavage and 1,6-anhydro sugar product synthesis by a peptidoglycan degrading lytic transglycosylase" Journal of Biological Chemistry., 293(16): 6000-6010. (2018).
Song, L., Merceron, R., Gracia, B., Quintana, A.L., Risseeuw, M.D.P., Hulpia, F., Cos, P., Ainsa, J.A., Munier-Lehmann, H., Savvides, S.N., Van Calenbergh, S. "Structure Guided Lead Generation towards non-chiral M. tuberculosis Thymidylate Kinase Inhibitors" Journal of Medicinal Chemistry., 61(7): 2753–2775. (2018).
Couturier, M., Ladevèze, S., Sulzenbacher, G., Ciano, L., Fanuel, M., Moreau, C., Villares, A., Cathala, B., Chaspoul, F., Frandsen, K.E., Labourel, A., Herpoël-Gimbert, I., Grisel, S., Haon, M., Lenfant, N., Rogniaux, H., Ropartz, D., Davies, G.J., Rosso, M.N., Walton, P.H., Henrissat, B., Berrin, J.G. "Lytic xylan oxidases from wood-decay fungi unlock biomass degradation" Nature Chemical Biology., 14(3): 306-310. (2018).