Identification of an Achilles heel in the dengue virus gives new hope for vaccine development

In association with Imperial College London, scientists at the Institut Pasteur and CNRS have identified a vulnerable site on the surface of the dengue virus which is targeted by the only broadly neutralizing antibodies identified to date. This discovery offers a new target for the development of a vaccine to combat all four types of dengue virus currently in circulation. These results were published in the journal Nature on January 12, 2015.

Illustration: 3D structure of the antibody complexes for all four serotypes bound to the dengue virus envelope protein.
© Institut Pasteur

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Rouvinski, A., Guardado-Calvo, P., Barba-Spaeth, G., Duquerroy, S., Vaney, M.C., Kikuti, C.M., Navarro Sanchez, M.E., Dejnirattisai, W., Wiyada Wongwiwat, W., Haouz, A., Girard-Blanc, C., Petres, S., Shepard, W., Desprès, P., Arenzana-Seisdedos, F., Dussart, P., Mongkolsapaya, J., Screaton, G.R., Rey, F.A. "Recognition determinants of broadly neutralizing human antibodies against dengue viruses" Nature., 520(7545): 109–113. (2015).

Rouvinski, A., Guardado-Calvo, P., Barba-Spaeth, G., Duquerroy, S., Vaney, M. C., Kikuti, C. M., Navarro Sanchez, M. E., Dejnirattisai, W., Wiyada Wongwiwat, W., Haouz, A., Girard-Blanc, C., Petres, S., Shepard, W., Desprès, P., Arenzana-Seisdedos, F., Dussart, P., Mongkolsapaya, J., Screaton, G. R. & Rey, F. A.
"Recognition determinants of broadly neutralizing human antibodies against dengue viruses."
Nature, 2015, 520, 109–113