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Dernière mise à jour : 05/10/2023
Durand, E., Nguyen, V.S., Zoued, A., Logger, L., Péhau-Arnaudet, G., Aschtgen, M.S., Spinelli, S., Desmyter, A., Bardiaux, B., Dujeancourt, A., Roussel, A., Cambillau, C., Cascales, E., Fronzes, R. "Biogenesis and structure of a type VI secretion membrane core complex" Nature., 523(7562): 555–560. (2015).
Bonnefond,, Stojko, J., Mailliot, J., Troffer-Charlier, N., Cura, V., Wurtz, J.M., Cianférani, S., Cavarelli, J. "Functional insights from high resolution structures of mouse Protein Arginine Methyltransferase 6" Journal of Structural Biology., 191(2): 175-183. (2015).
George, D. M., Breinlinger, E. C., Friedman, M., Zhang, Y., Wang, J., Argiriadi, M., Bansal-Pakala, P., Barth, M., Duignan, D.B., Honore, P., Lang, Q., Mittelstadt, S., Potin, D., Rundell, L., Edmunds, J.J. "Optimized protein kinase Cθ (PKCθ) inhibitors reveal only modest anti-inflammatory efficacy in a rodent model of arthritis." Journal of Medicinal Chemistry., 58(1): 222-236. (2015).
Goossens, K.V., Ielasi, F.S., Nookaew, I., Stals, I., Alonso-Sarduy, L., Daenen, L., Van Mulders, S.E., Stassen, C., van Eijsden, R.G., Siewers, V., Delvaux, F.R., Kasas, S., Nielsen, J., Devreese, B., Willaert, R.G. "Molecular Mechanism of Flocculation Self-Recognition in Yeast and Its Role in Mating and Survival" mBio., 6(2): art.n° e00427-00415. (2015).
Ferrer-Orta, C., de la Higuera, I., Caridi, F., Sanchez-Aparicio, M.T., Moreno, E., Perales, C., Singh, K., Sarafianos, S.G., Sobrino, F., Domingo, E., Verdaguer, N. "Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition" Journal of Virology., 89(13): 6848-6859. (2015).
Pasquier, B., El-Ahmad, Y., Filoche-Romme, B., Dureuil, C., Fassy, F., Abecassis, P., Mathieu, M., Bertrand, T., Benard, T., Barriere, C., El Batti, S., Letallec, J., Sonnefraud, V., Brollo, M., Delbarre, L., Loyau, V., Pilorge, F., Bertin, L., Richepin, P., Arigon, J., Labrosse, J., Clement, J., Durand, F., Combet, R., Perraut, P., Leroy, V., Gay, F., Lefrancois, D., Bretin, F., Marquette, J., Michot, N., Caron, A., Castell, C., Schio, L., Mccort, G., Goulaouic, H., Garcia-Echeverria, C., Ronan, B. "Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-Yl]-1-(3-Methyl-2-Oxobutyl)-2-(Trifluoromethyl)-3,4-Dihydro-2H-Pyrimido[1,2-A]Pyrimidin-6-One: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors" Journal of Medicinal Chemistry., 58(1): 376-400. (2015).
Wang, W., Shen, T., Guerois, R., Zhang, F., Kuerban, H., Lv, Y., Gigant, B., Knossow, M., Wang, C. "New Insights into the Coupling between Microtubule Depolymerization and ATP Hydrolysis by Kinesin-13 Protein Kif2C" Journal of Biological Chemistry., 290(30): 18721-18731. (2015).
Mori, G., Chiarelli, L.R., Esposito, M., Makarov, V., Bellinzoni, M., Hartkoorn, R.C., Degiacomi, G., Boldrin, F., Ekins, S., de Jesus Lopes Ribeiro, A.L., Marino, L.B., Centárová, I., Svetlíková, Z., Blaško, J., Kazakova, E., Lepioshkin, A., Barilone, N., Zanoni, G., Porta, A., Fondi, M., Fani, R., Baulard, A.R., Mikušová, K., Alzari, P.M., Manganelli, R., de Carvalho, L.P.S. "Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG" Chemistry & Biology., 22(7): 917–927. (2015).
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Valéry, C., Deville-Foillard, S., Lefebvre, C., Taberner, N., Legrand, P., Meneau, F., Meriadec, C., Delvaux, C., Bizien, T., Kasotakis, E., Lopez-Iglesias, C., Gall, A., Bressanelli, S., Le Du, M.H., Paternostre, M., Artzner, F. "Atomic view of the histidine environment stabilizing higher-pH conformations of pH-dependent proteins" Nature Communications., 6: art.n° 7771. (2015).